Although I did not get a chance to see Splice in theaters, I wanted to. As a fan of Vincenzo Natali's Cube films I thought this sounded interesting... and like Adrien Brody and Sarah Polley.
I'm kind of glad I waited to see this on DVD, because although I thought it was okay - it was just okay. I would have been disappointed if I had seen it in theaters because my expectations would have been higher.
It is a fairly small movie in terms of story, something you'd expect from Natali - but as usual, he presents some really interesting scientific and theoretical ideas. That's sort of where this loses its steam. Things, from a script and story perspective, start to unravel after they cross the DNA of a human with the animals they've been successful crossing. It's engaging, but seems to become less and less plausible as it progresses. And not because a half-human, half-multi-animal creature grows and exists. But because the actions taken by the two leads seem less and less plausible.
It ends with a battle scene that seems out of place for this film - almost like he was told he needed more action when there was probably a more intelligent way to end it. Although it falls off the rails a bit, Splice is a decent filma and Natali does a good job of holding what's left of the train together.